INFORMATION ON MYOSTATIN NT-821 AND A LINK TO THE AHCA INFORMATION ON IT
The Myostatin NT-821 deletion gene, also known as the “myostatin Del11” or “M1” mutation, is a genetic variant that results in increased muscle mass, a condition known as “double muscling”. Specifically, it involves an 11-base pair deletion of nucleotides 821-831 in the myostatin gene. This deletion disrupts the myostatin protein’s function, leading to reduced myostatin activity and increased muscle growth.
Elaboration:
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Myostatin and Muscle Growth:Myostatin is a protein that naturally inhibits muscle growth. When the myostatin gene is disrupted, like in the case of the NT-821 deletion, muscle growth is less constrained, resulting in increased muscle mass.
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Double Muscling:The NT-821 deletion is associated with double muscling, a condition characterized by excessive muscle development, particularly in the hindquarters and back of affected animals.
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Inheritance:The NT-821 deletion is inherited as a dominant trait in some breeds, meaning that even one copy of the mutation can cause double muscling.
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Breeds Affected:The NT-821 deletion is commonly found in breeds like Belgian Blue, Piedmontese, and Shorthorn cattle, and it can also be present in other breeds as well. It was just discovered in Scottish Highlands within the last several years.
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Impact on Meat Production:Double muscling can lead to higher carcass weight and increased meat yield, making it a desirable trait for some meat producers. However, it can also be associated with other traits, such as increased calving difficulty and potential health issues.
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Testing and Management:Genetic testing is available to identify animals carrying the NT-821 deletion, allowing breeders to make informed decisions about breeding practices and manage the presence of the mutation in their herds.